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Article

No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.

Journal of neuroimmunology - 1 Jun 2010

Handel Adam E, De Luca Gabriele C, Morahan Julia, Handunnetthi Lahiru, Sadovnick A Dessa, Ebers George C, Ramagopalan Sreeram V

Abstract excerpt

Multiple sclerosis (MS) is a complex neurological disease with huge variability in disease outcome. The majority of MS genetic susceptibility is determined by major histocompatibility complex (MHC) alleles, in particular haplotypes carrying HLA-DRB1*1501. HLA-DRB1*1501 also affects the clinical outcome of the disease and animal research has suggested that HLA-DRB5 interacts with HLA-DRB1*1501 to influence disease...

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Identifiers

PMID: 20394989
DOI: 10.1016/j.jneuroim.2010.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.PMID 20394989Read ↗

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Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studiesSemantic proximity Read ↗

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis.Semantic proximity Read ↗

An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.Semantic proximity Read ↗

Identification of HLA-DQA1 and HLA-DRB5 as Risk Factors for Multiple Sclerosis: An Epigenome-Wide Methylation Haplotype Association Analysis.Semantic proximity Read ↗

HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility.Semantic proximity Read ↗

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