Article
HLA-DRB1*1501 influences long-term disability progression and tissue damage on MRI in relapse-onset multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Mar 2023
Brownlee Wallace J, Tur Carmen, Manole Andreea, Eshaghi Arman, Prados Ferran, Miszkiel Katherine A, Wheeler-Kingshott Claudia Am Gandini, Houlden Henry, Ciccarelli Olga
Abstract excerpt
BACKGROUND: Whether genetic factors influence the long-term course of multiple sclerosis (MS) is unresolved. OBJECTIVE: To determine the influence of HLA-DRB1*1501 on long-term disease course in a homogeneous cohort of clinically isolated syndrome (CIS) patients. METHODS: One hundred seven patients underwent clinical and MRI assessment at the time of CIS and after 1, 3, 5 and 15 years. HLA-DRB1*1501 status was...
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