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Article

Multiple sclerosis: doubling down on MHC

15 May 2021

Abstract excerpt

Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T lymphocytes and play a key role in adaptive immune responses. Besides their physiological role of defending the host against infectious pathogens, specific alleles serve as genetic risk factors for autoimmune diseases. For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an association...

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Identifiers

PMID: 34006391
DOI: 10.1016/j.tig.2021.04.012

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