p53 as a prognostic factor in adrenocortical tumors of adults and children.

doi:10.1590/s0100-879x2003000100004

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Article

p53 as a prognostic factor in adrenocortical tumors of adults and children.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 2003

Sredni S T, Zerbini M C N, Latorre M R, Alves V A F

Abstract excerpt

Mutations of the tumor suppressor gene p53 have been considered to be important determinants in several kinds of human cancer. Accumulation of p53 protein has been reported to correlate with more aggressive clinical behavior in some neoplasms. The role of p53 expression in adrenal cortical tumors (ACT) has not been elucidated but some studies have suggested its correlation with malignant behavior. Our objective...

Topics

Adolescent
Adrenal Cortex Neoplasms
Adult
Biomarkers, Tumor
Child
Disease-Free Survival
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Immunohistochemistry
Mutation
Prognosis
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 12532223
DOI: 10.1590/s0100-879x2003000100004

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