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Article

Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors.

Virchows Archiv : an international journal of pathology - 1 Jan 1995

Chemeris G, Loktinov A, Rempel A, Schwarz M, Bannasch P

Abstract excerpt

p53 tumour suppressor gene expression was estimated immunohistochemically using DO-1 monoclonal antibody (recognising both wild-type and mutant p53 in 88 human renal tumours. Single strand conformation polymorphism (SSCP) analysis of possible mutations within exons 4-8 of the p53 gene was performed in 29 of the tumours (mostly immunostaining-positive cases). Obviously elevated p53 content was detected with DO-1...

Topics

Base Sequence
Carcinoma, Renal Cell
Genes, p53
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation
Polymorphism, Single-Stranded Conformational
Prognosis
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7655736
DOI: 10.1007/BF00192110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7655736-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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