Article
p53 molecule as a prognostic marker in human malignancies.
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society - 1 Apr 1998
Munshi A, Byrne P, Ramesh R, Freeman S M, Marrogi A J
Abstract excerpt
The tumor suppressor gene, p53, is the most commonly mutated gene associated with cancer. Mutation of p53 plays a critical role in the multiple stages of carcinogenesis. The functional inactivation of p53 by missense mutations has been described in various cancers and the majority of these mutations occur in exons 5 through 9 of the p53 gene. Mutations leading to the overexpression of p53 have been found to...
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