Towards an understanding of the role of p53 in adrenocortical carcinogenesis.

doi:10.1016/j.mce.2011.09.010

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Article

Towards an understanding of the role of p53 in adrenocortical carcinogenesis.

Molecular and cellular endocrinology - 31 Mar 2012

Wasserman Jonathan D, Zambetti Gerard P, Malkin David

Abstract excerpt

Adrenocortical carcinoma (ACC) is recognized to be a component tumor of the Li Fraumeni Syndrome (LFS), a familial cancer predisposition resulting from germline mutations in the p53 tumor-suppressor. p53 activity is tightly regulated by multiple post-translational mechanisms, disruption of which may lead to tumorigenesis. ACC is present in disproportionately high rates among p53-mutation carriers, suggesting...

Topics

Adolescent
Adrenal Cortex Neoplasms
Adrenocortical Carcinoma
Alleles
Animals
Cell Transformation, Neoplastic
Child
Child, Preschool
Humans
Infant
Li-Fraumeni Syndrome
Organ Specificity
Penetrance
Tumor Suppressor Protein p53

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Identifiers

PMID: 21930187
DOI: 10.1016/j.mce.2011.09.010
PMCID: PMC3288384

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