Article
p53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies.
The Journal of clinical endocrinology and metabolism - 1 Mar 1994
Reincke M, Karl M, Travis W H, Mastorakos G, Allolio B, Linehan H M, Chrousos G P
Abstract excerpt
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer. p53 is a recessive tumor suppressor gene located on chromosome 17p. Mutations in the p53 g...
Topics
- Adolescent
- Adrenal Cortex Neoplasms
- Adult
- Aged
- Base Sequence
- Exons
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53