Article
p53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies.
The Journal of clinical endocrinology and metabolism - 1 Mar 1994
Reincke M, Karl M, Travis W H, Mastorakos G, Allolio B, Linehan H M, Chrousos G P
Abstract excerpt
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer. p53 is a recessive tumor suppressor gene located on chromosome 17p. Mutations in the p53 gene play an important role in the tumorigenesis of diverse types of human neoplasms including breast and colon cancers....
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