Article
An inherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors.
The Journal of clinical endocrinology and metabolism - 1 Oct 2001
Latronico A C, Pinto E M, Domenice S, Fragoso M C, Martin R M, Zerbini M C, Lucon A M, Mendonca B B
Abstract excerpt
Mutations of the p53 tumor suppressor gene are the single most common genetic alterations in human cancers. Recently, a distinct nucleotide substitution was identified in exon 10 of the p53 gene, leading to an Arg337His mutation in 97% of children with adrenocortical tumors from Southern Brazil. In the present study, we investigated the presence of this mutation in a larger series of 55 patients (37 adults and 18...
Topics
- Adolescent
- Adrenal Cortex Neoplasms
- Adult
- Binding Sites
- Child
- Child, Preschool
- Conserved Sequence
- DNA
- Female
- Genes, p53
- Humans