Article
p53 protein alterations in human testicular cancer including pre-invasive intratubular germ-cell neoplasia.
International journal of cancer - 9 Sept 1991
Bártková J, Bártek J, Lukás J, Vojtĕsek B, Stasková Z, Rejthar A, Kovarík J, Midgley C A, Lane D P
Abstract excerpt
Expression of the p53 oncoprotein was examined in a wide range of primary human testicular germ-cell tumours using a new mouse monoclonal antibody (MAb) BP53-11 raised and characterized in this study, in parallel with a polyclonal rabbit antiserum CM-1. Immunohistochemistry on paraffin sections showed positive nuclear reaction in at least a fraction of malignant cells in 90 (84%) out of 107 cases studied....
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