Article
Inheritance of R337H p53 gene mutation in children with sporadic adrenocortical tumor.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Apr 2005
Sandrini F, Villani D P, Tucci S, Moreira A C, de Castro M, Elias L L K
Abstract excerpt
Adrenocortical tumors (ACTs) are frequent in Brazil. The mechanisms of adrenal tumorigenesis remain poorly established; the R337H germline mutation in the p53 gene has previously been associated with ACTs in Brazilian children. We investigated the frequency and inheritance of R337H p53 mutation as well as genotype and phenotype correlation in 21 children and 5 adult patients with ACTs. DNA was extracted from...
Topics
- Adrenal Cortex Neoplasms
- Adult
- Aged
- Brazil
- Child
- Child, Preschool
- Codon
- DNA
- Exons
- Female
- Genes, p53
- Genotype
- Humans
- Infant
- Male
- Middle Aged
- Mutation
- Phenotype