Article
Mutations of the p53 gene in human functional adrenal neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Feb 1994
Lin S R, Lee Y J, Tsai J H
Abstract excerpt
To clarify gene alterations in functional human adrenal tumors, we performed molecular analysis for p53 abnormalities in 23 cases with adrenal neoplasms. The immunohistochemical study with anti-p53 monoclonal antibody pAb1801 demonstrated that 10 of 23 (43.5%) cases overexpressed p53 protein in t...
Topics
- Adenoma
- Adrenal Gland Neoplasms
- Adult
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cloning, Molecular
- DNA, Neoplasm
- Exons
- Female
- Gene Amplification
- Genes, p53
- Guanosine Triphosphate
- Heterozygote
- Humans
- Immunohistochemistry
- Male
- Middle Aged