Article
Mutations of the p53 gene in human functional adrenal neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Feb 1994
Lin S R, Lee Y J, Tsai J H
Abstract excerpt
To clarify gene alterations in functional human adrenal tumors, we performed molecular analysis for p53 abnormalities in 23 cases with adrenal neoplasms. The immunohistochemical study with anti-p53 monoclonal antibody pAb1801 demonstrated that 10 of 23 (43.5%) cases overexpressed p53 protein in the tumor cells. Using a polymerase chain reaction-single strand conformation polymorphism study, 5 of 6 (83.3%)...
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