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Article

A Novel TP53 Mutation Associated with TWIST1 and SIP1 Expression in an Aggressive Adrenocortical Carcinoma.

Endocrine pathology - 1 Dec 2017

Bulzico Daniel, Torres Davi Coe, Ferreira Gerson Moura, Pires Bruno Ricardo Barreto, de Faria Paulo Antônio Silvestre, Hassan Rocio, Abdelhay Eliana, Vaisman Mario, Vieira Neto Leonardo

Abstract excerpt

Adrenocortical carcinomas (ACC) are very rare tumors related to TP53 mutations mostly in childhood onset cases. Epithelial-mesenchymal transition (EMT) transcription factors TWIST1 and Smad interacting protein 1 (SIP1) are related to poorer outcomes in other malignancies, but their role in ACC is unknown. We describe a case of an advanced metastatic ACC (Weiss-score of 9) in a patient at age 76. After primary...

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Source

Identifiers

PMID: 28421464
DOI: 10.1007/s12022-017-9482-7

Genes

TWIST1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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