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Article

Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.

Genes & development - 1 Jan 2003

Hesslein David G T, Pflugh David L, Chowdhury Dipanjan, Bothwell Alfred L M, Sen Ranjan, Schatz David G

Abstract excerpt

Pax5-deficient progenitor B (pro-B) cells are thought to be severely defective for recombination of all immunoglobulin heavy chain (IgH) V gene segments, but the mechanism by which Pax5 regulates this process has not been defined. To address this issue, we have examined the assembly of the IgH locus in Pax5-deficient pro-B cells and find, unexpectedly, that 3' IgH V gene segments, which lie closest to the D-J-Cmu...

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Share to DNA Nucleotidyltransferases
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Genes, RAG-1

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

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Source

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Identifiers

PMID: 12514097
DOI: 10.1101/gad.1031403
PMCID: PMC195966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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