Article
Transcriptional regulation in early B cell development.
Current opinion in immunology - 1 Apr 2007
Fuxa Martin, Skok Jane A
Abstract excerpt
Transcription factors and signalling molecules are important for both lineage commitment and lineage-specific regulation. The B cell specification factor Pax5 plays a dual role in B lineage commitment. Simultaneously, it potentiates and limits lineage choice by activating genes that are required for the B cell program while repressing lineage-inappropriate genes; more than 100 of the latter have now been...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Cell Lineage
- Forkhead Transcription Factors
- Gene Expression Regulation, Developmental
- Gene Rearrangement, B-Lymphocyte
- Lymphopoiesis
- Mice
- PAX5 Transcription Factor
- Repressor Proteins