Article
Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity.
The Journal of biological chemistry - 22 Apr 2011
He Ti, Hong Sang Yong, Huang Lin, Xue Weihua, Yu Zhihong, Kwon Hyoung, Kirk Marion, Ding Shi-jian, Su Kaihong, Zhang Zhixin
Abstract excerpt
Pax5/B cell lineage specific activator protein (BSAP) is a B lineage-specific regulator that controls the B lineage-specific gene expression program and immunoglobulin gene V(H) to DJ(H) recombination. Despite extensive studies on its multiple functions, little is known about how the activity of Pax5 is regulated. Here, we show that co-expression of histone acetyltransferase E1A binding protein p300 dramatically...
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