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Article

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.

Genes & development - 15 Feb 2004

Fuxa Martin, Skok Jane, Souabni Abdallah, Salvagiotto Giorgia, Roldan Esther, Busslinger Meinrad

Abstract excerpt

The subnuclear location and chromatin state of the immunoglobulin heavy-chain (IgH) locus have been implicated in the control of VDJ recombination. VH-to-DJH rearrangement of distal, but not proximal V(H) genes, furthermore, depends on the B-lineage commitment factor Pax5 (BSAP). He e we demonstrate that ectopic Pax5 expression from the Ikaros promote induces proximal rather than distal VH-DJH rearrangements in...

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Source

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Identifiers

PMID: 15004008
DOI: 10.1101/gad.291504
PMCID: PMC359395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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