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Article

[Is C3435T polymorphism of MDR1 related to inflammatory bowel disease or colorectal cancer in Korean?].

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi - 1 Jan 2006

Lee Bo-In, Choi Kyu-Yong, Lee Kang-Moon, Chung Woo-Chul, Kim Byung-Wook, Choi Hwang, Cho Se-Hyun, Kang Hyong-Ju, Lee Jin-Sun, Kim Myung-Seok, Chae Hiun-Suk, Chun In-Sik

Abstract excerpt

BACKGROUND/AIMS: Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein in intestinal epithelium, which serves as a transmembrane efflux pump of various toxins. mdr1 knockout mice develop spontaneous colitis under specific pathogen free conditions. However, it is unclear that C3435T polymorphism of MDR1 is related to ulcerative colitis. Other studies suggest MDR1 may have an important role in colorectal...

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Aged, 80 and over
Colorectal Neoplasms
Gene Frequency
Genes, MDR
Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

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PMID: 16434865

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