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Article

Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients.

European journal of clinical pharmacology - 1 Jul 2005

Kurzawski Mateusz, Droździk Marek, Suchy Janina, Kurzawski Grzegorz, Białecka Monika, Górnik Wanda, Lubiński Jan

Abstract excerpt

OBJECTIVE: The P-glycoprotein, a product of MDR1 (multiple drug resistance 1) gene, is a membrane efflux pump localized in epithelial cells in the small and large intestine, a part of the gastrointestinal barrier that protects cells against xenobiotics from our diet, bacterial toxins, drugs and other biologically active compounds, possibly carcinogens. In the present study, an association of MDR1 gene...

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Identifiers

PMID: 15912392
DOI: 10.1007/s00228-005-0926-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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