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Article

A novel p53 mutant retained functional activity in lung carcinomas.

DNA repair - 4 Sept 2002

Ko Jiunn-Liang, Chiao Ming-Chiang, Chang Shu-Lin, Lin Pinpin, Lin Jin-Ching, Sheu Gwo-Tarng, Lee Huei

Abstract excerpt

The gene p53 is a critical tumor suppressor that can respond to multiple signals of cellular gatekeepers for growth and division. The mdm2 gene is one of the downstream target genes for transcriptional activation by the product of p53 tumor suppressor gene. Transactivation of mdm2 gene is represented by the presence of a functional P53 protein. To understand the biological function of mutant p53 in tumorigenesis,...

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PMID: 12509279
DOI: 10.1016/s1568-7864(02)00094-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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