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Article

Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non-small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 2005

Wang Yu-Chien, Lin Ruo-Kai, Tan Yi-Hung, Chen Jung-Ta, Chen Chih-Yi, Wang Yi-Ching

Abstract excerpt

PURPOSE: We found a relatively reduced frequency of p53 mutation with a much greater frequency of p53 protein overexpression, which reflected stabilization of p53 protein in the absence of p53 gene mutation. Therefore, we investigated the possibility of alternative mechanisms leading to p53 protein stabilization. PATIENTS AND METHODS: We performed gene and protein alteration studies on p53 and its upstream...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Genes, p53

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Nuclear Proteins

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Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p14ARF

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Source

Identifiers

PMID: 15625370
DOI: 10.1200/JCO.2005.03.139

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non-small-cell lung cancer.PMID 15625370Read ↗

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