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Article

Tumor-derived p53 mutants induce NF-kappaB2 gene expression.

Molecular and cellular biology - 1 Nov 2005

Scian Mariano J, Stagliano Katherine E R, Anderson Michelle A E, Hassan Sajida, Bowman Melissa, Miles Mike F, Deb Swati Palit, Deb Sumitra

Abstract excerpt

Overexpression of mutant p53 is a common theme in tumors, suggesting a selective pressure for p53 mutation in cancer development and progression. To determine how mutant p53 expression may lead to survival advantage in human cancer cells, we generated stable cell lines expressing p53 mutants p53-R175H, -R273H, and -D281G by use of p53-null human H1299 (lung carcinoma) cells. Compared to vector-transfected cells,...

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Adenoviridae
Bromodeoxyuridine
Etoposide
Genetic Vectors
NF-kappa B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Small Interfering

Transcriptional Activation

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Identifiers

PMID: 16260623
DOI: 10.1128/MCB.25.22.10097-10110.2005
PMCID: PMC1280285

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