Article
Absence of mutations in the functional domains of the human MDM2 oncogene in non-small cell lung carcinomas.
Mutation research - 30 Nov 2000
Mariatos G, Gorgoulis V G, Kotsinas A, Zacharatos P, Kokotas S, Yannoukakos D, Kittas C
Abstract excerpt
Increasing evidence suggests that MDM2 oncoprotein participates in a complex array of interactions with a plethora of molecules, including cell-cycle and transcriptional regulators, as well as determinants of the cell differentiation and senescence. The tumorigenic potential of MDM2 is mainly determined by overexpression due to gene amplification, mRNA overexpression and possibly translational enhancement....
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