Article
Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.
Oncogene - 1 Jun 1995
Forrester K, Lupold S E, Ott V L, Chay C H, Band V, Wang X W, Harris C C
Abstract excerpt
The spectrum of p53 mutations differs among human cancer types. We have hypothesized that the p53 mutational spectrum observed in particular tumor types reflects the functional ability of different p53 mutants to modulate wild-type (WT) p53-dependent gene transcription. Missense p53 mutants repre...
Topics
- Base Sequence
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasms
- Oligodeoxyribonucleotides
- Protein Conformation
- Transcriptional Activation
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53