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Article

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.

Oncogene - 1 Jun 1995

Forrester K, Lupold S E, Ott V L, Chay C H, Band V, Wang X W, Harris C C

Abstract excerpt

The spectrum of p53 mutations differs among human cancer types. We have hypothesized that the p53 mutational spectrum observed in particular tumor types reflects the functional ability of different p53 mutants to modulate wild-type (WT) p53-dependent gene transcription. Missense p53 mutants representing several mutational hotspot codons were cotransfected with WT p53 and analysed for their effects on...

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PMID: 7784055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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