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Article

Identification of a tumor-derived p53 mutant with novel transactivating selectivity.

Oncogene - 22 Jun 2000

Pan Y, Haines D S

Abstract excerpt

MDM2 is a p53-responsive molecule that when overexpressed, can alter growth control pathways via p53-dependent and independent mechanisms. We have identified a mutant p53 containing line that expresses high levels of transcripts that are regulated by the p53-responsive promoter of the MDM2 gene. Analysis of cloned product obtained from these tumor cells revealed that they harbor a mutant p53 protein (possessing...

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Source

Identifiers

PMID: 10871862
DOI: 10.1038/sj.onc.1203663

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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