Article
Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.
British journal of cancer - 1 Jan 1998
Gorgoulis V G, Zacharatos P V, Manolis E, Ikonomopoulos J A, Damalas A, Lamprinopoulos C, Rassidakis G Z, Zoumpourlis V, Kotsinas A, Rassidakis A N, Halazonetis T D, Kittas C
Abstract excerpt
The present study represents a continuation of previous works in which we observed that lung carcinomas co-expressing MDM2 protein and p53 mutants (mt p53) exhibited more aggressive behaviour. In the above studies, we suggested a 'gain of function' mechanism of mt p53 proteins based on the fact that the MDM2 gene possesses a p53-responsive element (MDM2-p53RE). In this study, to prove our hypothesis, we selected...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.