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Oncogenes and tumor-suppressor genes.

1 Jun 1991

Abstract excerpt

The functional role of oncogenes in human lung carcinogenesis has been investigated by transfer of activated oncogenes into normal cells or an immortalized bronchial epithelial cell line, BEAS-2B. Transfection of v-Ha-ras, Ki-ras, or the combination of myc and raf into BEAS-2B cells produced tumorigenic cell lines, while transfection of raf or myc alone produced nontumorigenic cell lines. In addition to studying...

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PMID: 1685442
DOI: 10.1289/ehp.9193133

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