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Article

Allele specific gain-of-function activity of p53 mutants in lung cancer cells.

Biochemical and biophysical research communications - 9 Nov 2012

Vaughan Catherine A, Frum Rebecca, Pearsall Isabella, Singh Shilpa, Windle Brad, Yeudall Andrew, Deb Swati P, Deb Sumitra

Abstract excerpt

p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with "gain of function" (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different endogenous p53 mutants results in loss of GOF activity as shown by lowering of cell growth rate. Two lung cancer...

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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, p53

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Source

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Identifiers

PMID: 22989750
DOI: 10.1016/j.bbrc.2012.09.029
PMCID: PMC4731231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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