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Article

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly.

European journal of cell biology - 1 Nov 2002

Zhang Chuanmao, Goldberg Martin W, Moore William J, Allen Terence D, Clarke Paul R

Abstract excerpt

Nuclear envelope (NE) formation can be studied in a cell-free system made from Xenopus eggs. In this system, NE formation involves the small GTPase Ran. Ran associates with chromatin early in nuclear assembly and concentration of Ran on inert beads is sufficient to induce NE formation. Here, we show that Ran binds to chromatin prior to NE formation and recruits RCC1, the nucleotide exchange factor that generates...

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Source

Identifiers

PMID: 12494999
DOI: 10.1078/0171-9335-00288

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly.PMID 12494999Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

Role of importin-beta in the control of nuclear envelope assembly by Ran.Semantic proximity Read ↗

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.Semantic proximity Read ↗

Dynamic localisation of Ran GTPase during the cell cycle.Semantic proximity Read ↗

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.Semantic proximity Read ↗

The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.Semantic proximity Read ↗

The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.Semantic proximity Read ↗

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.Semantic proximity Read ↗

Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.Semantic proximity Read ↗

Spatial and temporal coordination of mitosis by Ran GTPase.Semantic proximity Read ↗

The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis.Semantic proximity Read ↗

The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport.Semantic proximity Read ↗

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