Article
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis.
The EMBO journal - 1 Dec 2021
Holzer Guillaume, De Magistris Paola, Gramminger Cathrin, Sachdev Ruchika, Magalska Adriana, Schooley Allana, Scheufen Anja, Lennartz Birgitt, Tatarek-Nossol Marianna, Lue Hongqi, Linder Monika I, Kutay Ulrike, Preisinger Christian, Moreno-Andres Daniel, Antonin Wolfram
Abstract excerpt
During mitotic exit, thousands of nuclear pore complexes (NPCs) assemble concomitant with the nuclear envelope to build a transport-competent nucleus. Here, we show that Nup50 plays a crucial role in NPC assembly independent of its well-established function in nuclear transport. RNAi-mediated downregulation in cells or immunodepletion of Nup50 protein in Xenopus egg extracts interferes with NPC assembly. We...
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