Article
A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.
The EMBO journal - 1 Dec 1994
Dasso M, Seki T, Azuma Y, Ohba T, Nishimoto T
Abstract excerpt
The Ran protein is a small GTPase that has been implicated in a large number of nuclear processes including transport. RNA processing and cell cycle checkpoint control. A similar spectrum of nuclear activities has been shown to require RCC1, the guanine nucleotide exchange factor (GEF) for Ran. W...
Topics
- Animals
- Cell Cycle Proteins
- Cell Nucleus
- Chromosomes
- DNA Replication
- DNA-Binding Proteins
- GTP-Binding Proteins
- Guanine Nucleotide Exchange Factors
- Humans
- Mutation
- Nuclear Proteins
- Ovum