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Article

Spatial and temporal coordination of mitosis by Ran GTPase.

Nature reviews. Molecular cell biology - 1 Jun 2008

Clarke Paul R, Zhang Chuanmao

Abstract excerpt

The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide...

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PMID: 18478030
DOI: 10.1038/nrm2410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of importin-beta in the control of nuclear envelope assembly by Ran.Semantic proximity Read ↗

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.Semantic proximity Read ↗

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle lengthSemantic proximity Read ↗

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.Semantic proximity Read ↗

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