The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.

doi:10.1242/jcs.111.20.3017

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Article

The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.

Journal of cell science - 1 Oct 1998

Hughes M, Zhang C, Avis J M, Hutchison C J, Clarke P R

Abstract excerpt

The Ran GTPase plays a critical role in nucleocytoplasmic transport and has been implicated in the maintenance of nuclear structure and cell cycle control. Here, we have investigated its role in nuclear assembly and DNA replication using recombinant wild-type and mutant Ran proteins added to a ce...

Topics

Animals
Biological Transport
Carrier Proteins
Cell Nucleus
Cell-Free System
DNA Replication
GTP Phosphohydrolases
GTP-Binding Proteins
Guanosine Diphosphate
Karyopherins
Mutation
Nuclear Envelope

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Localization Signals

Nuclear Proteins

Nucleocytoplasmic Transport Proteins

Nucleoplasmins

Ovum

Phosphoproteins

Source

Open in PubMed

Identifiers

PMID: 9739075
DOI: 10.1242/jcs.111.20.3017

Genes

PCNA
RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9739075-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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