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Article

The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.

Journal of cell science - 1 Oct 1998

Hughes M, Zhang C, Avis J M, Hutchison C J, Clarke P R

Abstract excerpt

The Ran GTPase plays a critical role in nucleocytoplasmic transport and has been implicated in the maintenance of nuclear structure and cell cycle control. Here, we have investigated its role in nuclear assembly and DNA replication using recombinant wild-type and mutant Ran proteins added to a cell-free system of Xenopus egg extracts. RanQ69L and RanT24N prevent lamina assembly, PCNA accumulation and DNA...

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Source

Identifiers

PMID: 9739075
DOI: 10.1242/jcs.111.20.3017

Genes

PCNA
RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.PMID 9739075Read ↗

Role of importin-beta in the control of nuclear envelope assembly by Ran.Semantic proximity Read ↗

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.Semantic proximity Read ↗

The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport.Semantic proximity Read ↗

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.Semantic proximity Read ↗

Dynamic localisation of Ran GTPase during the cell cycle.Semantic proximity Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

The Ran GTPase cycle is required for yeast nuclear pore complex assembly.Semantic proximity Read ↗

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Semantic proximity Read ↗

Spatial and temporal coordination of mitosis by Ran GTPase.Semantic proximity Read ↗

The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis.Semantic proximity Read ↗

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.Semantic proximity Read ↗

The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport.Semantic proximity Read ↗

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