Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport.

Molecular biology of the cell - 1 Oct 1997

Pu R T, Dasso M

Abstract excerpt

Ran is a small GTPase that is essential for nuclear transport, mRNA processing, maintenance of structural integrity of nuclei, and cell cycle control. RanBP1 is a highly conserved Ran guanine nucleotide dissociation inhibitor. We sought to use Xenopus egg extracts for the development of an in vitro assay for RanBP1 activity in nuclear assembly, protein import, and DNA replication. Surprisingly, when we used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Biological Transport

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to DNA-Binding Proteins

Share to Fungal Proteins

Share to Gene Expression

Share to Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 9348536
DOI: 10.1091/mbc.8.10.1955
PMCID: PMC25650

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport.PMID 9348536Read ↗

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.Semantic proximity Read ↗

The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.Semantic proximity Read ↗

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.Semantic proximity Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly.Semantic proximity Read ↗

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.Semantic proximity Read ↗

Role of importin-beta in the control of nuclear envelope assembly by Ran.Semantic proximity Read ↗

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.Semantic proximity Read ↗

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.Semantic proximity Read ↗

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.Semantic proximity Read ↗

The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.Semantic proximity Read ↗

A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.