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Article

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.

BMC cell biology - 21 Jun 2010

Hitakomate Ekarat, Hood Fiona E, Sanderson Helen S, Clarke Paul R

Abstract excerpt

BACKGROUND: Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Both the N-terminal tail of RCC1 and its association with Ran are important for its interaction with chromatin in cells. In vitro, the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20565941
DOI: 10.1186/1471-2121-11-43
PMCID: PMC2898669

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.PMID 20565941Read ↗

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