Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.

Molecular and cellular biology - 1 May 2000

Plafker K, Macara I G

Abstract excerpt

The Ran binding protein RanBP1 is localized to the cytosol of interphase cells. A leucine-rich nuclear export signal (NES) near the C terminus of RanBP1 is essential to maintain this distribution. We now show that RanBP1 accumulates in nuclei of cells treated with the export inhibitor, leptomycin B, and collapse of the nucleocytoplasmic Ran:GTP gradient leads to equilibration of RanBP1 across the nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport, Active
Share to Cell Compartmentation
Share to Exportin 1 Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fatty Acids, Unsaturated

Share to Guanine Nucleotide Exchange Factors

Share to Guanosine Triphosphate

Share to Karyopherins

Share to ran GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 10779340
DOI: 10.1128/MCB.20.10.3510-3521.2000
PMCID: PMC85643

Genes

NES
RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.PMID 10779340Read ↗

Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.Semantic proximity Read ↗

The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis.Semantic proximity Read ↗

UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities.Semantic proximity Read ↗

Role of importin-beta in the control of nuclear envelope assembly by Ran.Semantic proximity Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

Nuclear export of signal recognition particle RNA in mammalian cells.Semantic proximity Read ↗

CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function.Semantic proximity Read ↗

Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.Semantic proximity Read ↗

Importin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly.Semantic proximity Read ↗

Crm1 is a mitotic effector of Ran-GTP in somatic cells.Semantic proximity Read ↗

Dynamic localization of the nuclear import receptor and its interactions with transport factors.Semantic proximity Read ↗

The Ins and Outs of Nuclear Trafficking: Unusual Aspects in Apicomplexan ParasitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.