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Article

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.

Nature - 8 Jul 1999

Carazo-Salas R E, Guarguaglini G, Gruss O J, Segref A, Karsenti E, Mattaj I W

Abstract excerpt

Chromosomes are segregated by two antiparallel arrays of microtubules arranged to form the spindle apparatus. During cell division, the nucleation of cytosolic microtubules is prevented and spindle microtubules nucleate from centrosomes (in mitotic animal cells) or around chromosomes (in plants and some meiotic cells). The molecular mechanism by which chromosomes induce local microtubule nucleation in the absence...

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Source

Identifiers

PMID: 10408446
DOI: 10.1038/22133

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.PMID 10408446Read ↗

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.Semantic proximity Read ↗

Crm1 is a mitotic effector of Ran-GTP in somatic cells.Semantic proximity Read ↗

Microtubule Nucleation in Mitosis by a RanGTP-Dependent Protein ComplexSemantic proximity Read ↗

Spatial and temporal coordination of mitosis by Ran GTPase.Semantic proximity Read ↗

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly.Semantic proximity Read ↗

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.Semantic proximity Read ↗

The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.Semantic proximity Read ↗

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle lengthSemantic proximity Read ↗

Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cellsSemantic proximity Read ↗

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran.Semantic proximity Read ↗

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.Semantic proximity Read ↗

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.Semantic proximity Read ↗

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