An additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families.

doi:10.1023/a:1020500720254

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Article

An additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families.

Lifetime data analysis - 1 Dec 2002

Li Hongzhe

Abstract excerpt

Many late-onset complex diseases exhibit variable age of onset. Efficiently incorporating age of onset information into linkage analysis can potentially increase the power of dissecting complex diseases. In this paper, we treat age of onset as a genetic trait with censored observations. We use mu...

Topics

Adult
Age of Onset
Aged
Breast Neoplasms
Genetic Linkage
Genetic Predisposition to Disease
Humans
Middle Aged
Models, Genetic
Nuclear Family
United States

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