Article

An efficient and accurate frailty model approach for genome-wide survival association analysis controlling for population structure and relatedness in large-scale biobanks

2020-11-01

Abstract excerpt

With decades of electronic health records linked to genetic data, large biobanks provide unprecedented opportunities for systematically understanding the genetics of the natural history of complex diseases. Genome-wide survival association analysis can identify genetic variants associated with ages of onset, disease progression and lifespan. We developed an efficient and accurate frailty (random effects) model app...

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Literature Corpus work: 4c96279f-58fd-5727-ac77-088481ce764c
DOI: 10.1101/2020.10.31.358234

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