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Article

Score test for age at onset genetic linkage analysis in selected sibling pairs.

Statistics in medicine - 30 Jun 2009

Callegaro A, van Houwelingen H C, Houwing-Duistermaat J J

Abstract excerpt

A new score statistic is derived, which uses information from registries (age-specific incidences) and family studies (sib-sib marginal correlation) to weight affected sibling pairs according to their age at onset. Age at onset of sibling pairs is modelled by a gamma frailty model. From this model we derive a bivariate survival function, which depends on the marginal survival and on the marginal correlation. The...

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Source

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PMID: 19402027
DOI: 10.1002/sim.3596

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NPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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