Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling hazard functions in families.

Genetic epidemiology - 1 Jan 1998

Siegmund K, McKnight B

Abstract excerpt

A genetic frailty model is presented for censored age of onset data in nuclear families where individuals carrying a genetic susceptibility gene have an increased risk of becoming affected. We use maximum likelihood via the EM algorithm to estimate the genetic relative risk and the allele frequency under a dominant susceptibility type and a proportional hazards model. When sampling is from a disease registry,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Age of Onset
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Cohort Studies

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Models, Genetic

Source

Identifiers

PMID: 9554553
DOI: 10.1002/(SICI)1098-2272(1998)15:2<147::AID-GEPI4>3.0.CO;2-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling hazard functions in families.PMID 9554553Read ↗

An additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families.Semantic proximity Read ↗

A frailty-model-based approach to estimating the age-dependent penetrance function of candidate genes using population-based case-control study designs: an application to data on the BRCA1 gene.Semantic proximity Read ↗

The additive genetic gamma frailty model for linkage analysis of age-of-onset variation.Semantic proximity Read ↗

Practical implementation of frailty models in Mendelian risk prediction.Semantic proximity Read ↗

Missing genetic information in case-control family data with general semi-parametric shared frailty model.Semantic proximity Read ↗

Modeling disease incidence rates in families.Semantic proximity Read ↗

Family-based association test for time-to-onset data with time-dependent differences between the hazard functions.Semantic proximity Read ↗

Using family members to augment genetic case-control studies of a life-threatening disease.Semantic proximity Read ↗

Risk models in genetic epidemiology.Semantic proximity Read ↗

Multivariate logistic regression for familial aggregation in age at disease onset.Semantic proximity Read ↗

Computing Individual Risks Based on Family History in Genetic Disease in the Presence of Competing Risks.Semantic proximity Read ↗

Family-based association tests for survival and times-to-onset analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.