Modeling hazard functions in families.

doi:10.1002/(SICI)1098-2272(1998)15:2<147::AID-GEPI4>3.0.CO;2-3

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Article

Modeling hazard functions in families.

Genetic epidemiology - 1 Jan 1998

Siegmund K, McKnight B

Abstract excerpt

A genetic frailty model is presented for censored age of onset data in nuclear families where individuals carrying a genetic susceptibility gene have an increased risk of becoming affected. We use maximum likelihood via the EM algorithm to estimate the genetic relative risk and the allele frequen...

Topics

Adolescent
Adult
Age of Onset
Algorithms
Alleles
Breast Neoplasms
Cohort Studies
Computer Simulation
Family Health
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Likelihood Functions
Models, Genetic
Registries
Risk Assessment
Selection Bias

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