Article
The additive genetic gamma frailty model for linkage analysis of age-of-onset variation.
Annals of human genetics - 1 Sept 1999
Li H
Abstract excerpt
Age of onset is a key factor in the linkage analysis of many complex diseases. Current methods in nonparametric linkage analysis are mainly concentrated on the affected relative pairs or affected family members with age of onset information either ignored or taken into account by specifying age-dependent penetrances for liability classes. On the other hand, gamma frailty models were developed in the biostatistics...
Topics
- Age Factors
- Age of Onset
- Algorithms
- Alleles
- Genetic Linkage
- Genetic Variation
- Humans
- Likelihood Functions
- Lod Score
- Models, Genetic
- Models, Statistical
- Pedigree