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Article

Practical implementation of frailty models in Mendelian risk prediction.

Genetic epidemiology - 1 Sept 2020

Huang Theodore, Gorfine Malka, Hsu Li, Parmigiani Giovanni, Braun Danielle

Abstract excerpt

There are numerous statistical models used to identify individuals at high risk of cancer due to inherited mutations. Mendelian models predict future risk of cancer by using family history with estimated cancer penetrances (age- and sex-specific risk of cancer given the genotype of the mutations) and mutation prevalences. However, there is often residual risk heterogeneity across families even after accounting...

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PMID: 32506746
DOI: 10.1002/gepi.22323
PMCID: PMC7895423

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