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Article

Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks.

Nature communications - 16 Sept 2022

Dey Rounak, Zhou Wei, Kiiskinen Tuomo, Havulinna Aki, Elliott Amanda, Karjalainen Juha, Kurki Mitja, Qin Ashley, Lee Seunggeun, Palotie Aarno, Neale Benjamin, Daly Mark, Lin Xihong

Abstract excerpt

With decades of electronic health records linked to genetic data, large biobanks provide unprecedented opportunities for systematically understanding the genetics of the natural history of complex diseases. Genome-wide survival association analysis can identify genetic variants associated with ages of onset, disease progression and lifespan. We propose an efficient and accurate frailty model approach for...

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PMID: 36114182
DOI: 10.1038/s41467-022-32885-x
PMCID: PMC9481565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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