Extensions to sib-pair linkage tests applicable to disorders characterized by delayed onset.

doi:10.1002/gepi.1370070607

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Article

Extensions to sib-pair linkage tests applicable to disorders characterized by delayed onset.

Genetic epidemiology - 1 Jan 1990

Dawson D V, Kaplan E B, Elston R C

Abstract excerpt

Extensions of the approach to sib-pair linkage tests developed by Haseman and Elston [Behav Genet 2:3-19, 1972] are proposed which incorporate information on age of onset and age at examination. Alternate sources for the age of onset corrections are described, including models for the estimation...

Topics

Age Factors
Aged
Aged, 80 and over
Alzheimer Disease
Genetic Diseases, Inborn
Genetic Linkage
Genetic Predisposition to Disease
Genetic Techniques
Genotype
Humans
Middle Aged
Models, Statistical
Phenotype

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