Score tests of genetic association in the presence of linkage based on the additive genetic gamma frailty model.

doi:10.1093/biostatistics/5.2.307

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Article

Score tests of genetic association in the presence of linkage based on the additive genetic gamma frailty model.

Biostatistics (Oxford, England) - 1 Apr 2004

Zhong Xiaoyun, Li Hongzhe

Abstract excerpt

Nuclear families with multiple affected sibs are often collected for genetic linkage analysis of complex diseases. Once linkage evidence is established, dense markers are often typed in the linked region for genetic association analysis based on linkage disequilibrium (LD). Detection of associati...

Topics

Adult
Age of Onset
Alleles
Child
Computer Simulation
Female
Genetic Predisposition to Disease
Humans
Likelihood Functions
Linkage Disequilibrium
Male
Models, Genetic
Siblings
Survival Analysis

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