Article
A phylogenetic analysis identifies heterogeneity among hepatocellular carcinomas.
Hepatology (Baltimore, Md.) - 1 Dec 2002
McGlynn Katherine A, Edmonson Michael N, Michielli Rita A, London W Thomas, Lin Wen Yao, Chen Gong-Chao, Shen Fu-Min, Buetow Kenneth H
Abstract excerpt
Primary hepatocellular carcinoma (HCC) is a significant cause of cancer morbidity and mortality on the global scale. Although epidemiologic studies have identified major risk factors for HCC, the sequence of oncogenic events at the molecular level remains poorly understood. While genetic allele loss appears to be a common event, the significance of the loss is not clear. In order to determine whether allele loss...
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