Article
Comprehensive allelotyping of human hepatocellular carcinoma.
Oncogene - 19 Jun 1997
Nagai H, Pineau P, Tiollais P, Buendia M A, Dejean A
Abstract excerpt
Hepatocellular carcinoma (HCC) is one of the most common cancers in many parts of the world, however the molecular mechanisms underlying liver cell transformation remain obscure. A genome-wide scan of loss of heterozygosity (LOH) in tumors provides a powerful tool to search for genes involved in neoplastic processes. To identify recurrent genetic alterations in liver tumors, we examined DNAs isolated from 120...
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