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Article

Allelic loss of chromosome 4q21 approximately 23 associates with hepatitis B virus-related hepatocarcinogenesis and elevated alpha-fetoprotein.

Hepatology (Baltimore, Md.) - 1 Oct 2004

Yeh Shiou-Hwei, Lin Ming-Wei, Lu Shu-Fen, Wu Dai-Chen, Tsai Shih-Feng, Tsai Ching-Yi, Lai Ming-Yang, Hsu Hey-Chi, Chen Ding-Shinn, Chen Pei-Jer

Abstract excerpt

Allelic loss of chromosome 4q is one of the most frequent genetic aberrations found in human hepatocellular carcinoma (HCC) and suggests the presence of putative tumor suppressor genes within this region. To precisely define the region containing these tumor suppressor genes for further positional cloning, we tried a detailed deletion mapping strategy in 149 HCCs by using 49 microsatellite markers covering 4q12...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15382172
DOI: 10.1002/hep.20409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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