Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma.

Article

Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma.

Cancer - 1 Sept 1997

Piao Z, Kim H, Jeon B K, Lee W J, Park C

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common human tumors in Asia and Africa. The molecular genetic changes involving both protooncogenes and tumor suppressor genes are known to be involved in hepatocarcinogenesis, but the roles of the known tumor suppressor genes in hepat...

Topics

Adult
Aged
Alleles
Carcinoma, Hepatocellular
Cell Differentiation
Female
Gene Deletion
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Heterozygote
Humans
Liver Neoplasms
Male
Microsatellite Repeats
Middle Aged

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